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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EDC3
All Species:
26.97
Human Site:
S441
Identified Species:
53.94
UniProt:
Q96F86
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96F86
NP_001135915.1
508
56078
S441
Q
N
R
A
P
V
L
S
I
D
P
P
V
H
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001097687
287
31155
R228
E
C
F
V
P
E
P
R
E
S
K
D
S
G
L
Dog
Lupus familis
XP_867080
508
56081
S441
R
N
R
A
P
V
L
S
I
D
P
P
V
H
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8K2D3
508
55939
S441
Q
N
R
A
P
V
L
S
I
D
P
P
V
H
E
Rat
Rattus norvegicus
XP_001072079
506
55875
S439
Q
N
R
A
P
V
L
S
I
D
P
P
V
H
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZLS2
506
56018
S439
Q
N
R
A
P
V
L
S
I
D
P
P
I
S
E
Frog
Xenopus laevis
Q5XH48
505
55557
N438
H
N
R
A
P
V
L
N
I
D
P
P
V
G
D
Zebra Danio
Brachydanio rerio
Q502M5
507
54834
S440
Q
N
R
A
P
V
L
S
I
D
P
P
V
S
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VVI2
680
73397
A579
V
N
R
A
S
V
L
A
I
D
P
P
P
C
G
Honey Bee
Apis mellifera
XP_392618
616
68864
A548
N
N
R
A
P
I
L
A
I
E
P
P
A
T
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_787406
618
67525
S554
T
N
K
A
P
I
L
S
L
D
P
S
N
T
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39998
551
61322
S464
R
G
S
T
K
V
W
S
L
D
I
P
N
G
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
53.5
96.4
N.A.
95.6
95.8
N.A.
N.A.
88.3
75.1
68.9
N.A.
26.9
30.3
N.A.
35.2
Protein Similarity:
100
N.A.
55.3
98.2
N.A.
97.8
98
N.A.
N.A.
94
85.4
80.3
N.A.
45.2
47
N.A.
51.6
P-Site Identity:
100
N.A.
6.6
93.3
N.A.
100
100
N.A.
N.A.
86.6
73.3
86.6
N.A.
60
53.3
N.A.
46.6
P-Site Similarity:
100
N.A.
13.3
100
N.A.
100
100
N.A.
N.A.
93.3
86.6
86.6
N.A.
66.6
73.3
N.A.
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
39.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
84
0
0
0
17
0
0
0
0
9
0
0
% A
% Cys:
0
9
0
0
0
0
0
0
0
0
0
0
0
9
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
84
0
9
0
0
9
% D
% Glu:
9
0
0
0
0
9
0
0
9
9
0
0
0
0
42
% E
% Phe:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
9
% F
% Gly:
0
9
0
0
0
0
0
0
0
0
0
0
0
25
25
% G
% His:
9
0
0
0
0
0
0
0
0
0
0
0
0
34
0
% H
% Ile:
0
0
0
0
0
17
0
0
75
0
9
0
9
0
0
% I
% Lys:
0
0
9
0
9
0
0
0
0
0
9
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
84
0
17
0
0
0
0
0
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
9
84
0
0
0
0
0
9
0
0
0
0
17
0
0
% N
% Pro:
0
0
0
0
84
0
9
0
0
0
84
84
9
0
0
% P
% Gln:
42
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% Q
% Arg:
17
0
75
0
0
0
0
9
0
0
0
0
0
0
0
% R
% Ser:
0
0
9
0
9
0
0
67
0
9
0
9
9
17
0
% S
% Thr:
9
0
0
9
0
0
0
0
0
0
0
0
0
17
0
% T
% Val:
9
0
0
9
0
75
0
0
0
0
0
0
50
0
0
% V
% Trp:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _